In our lab, we are interested in looking into the mechanisms behind sex-specific differences in lung diseases as it pertains to Neonatology.
Our unique niche is to elucidate the mechanisms sex-specific differences in neonatal hyperoxic lung injury with the goal to develop individualized therapeutic options to decrease morbidity in preterm babies. Sex-specific differences exist in various forms of organ injury in adults and children. Neonatal outcomes for males are worse than females for many diseases, including bronchopulmonary dysplasia (BPD). Being a neonatologist, Dr. Lingappan's interest was in the field of neonatal lung injury and repair.
Meet the rest of the lab ๐ฉโ๐ฌBronchopulmonary dysplasia (BPD), a debilitating lung disease with long-term consequences, is the most common morbidity in extremely premature neonates. Male babies have a higher incidence of BPD compared to females. We study how lung injury and repair is different between male and female neonates and elucidate the molecular mechanisms modulating these sex-specific differences.
Sprouting Angiogenesis in male and female human pulmonary microvascular endothelial cells.
Sex-related external factors influence pulmonary vascular angiogenesis in a sex-dependent manner.
Hayward-Piatkovskyi B,Gonyea CR,Pyle SC,Lingappan K,Gleghorn JP
The Need to Address Sex as a Biological Variable in Neonatal Clinical Studies.
Lingappan K,Alur P,Eichenwald E
Lung biopsy in infants with severe bronchopulmonary dysplasia.
Callaway DA,Wang Y,Lingappan K,Pogoriler JE,Laje P,Nilan K,Kirpalani H,Zhang H
Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates.
Lingappan K,Neveln N,Arnold JL,Fernandes CJ,Pammi M
Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation.
Grimm SL,Stading RE,Robertson MJ,Gandhi T,Fu C,Jiang W,Xia G,Lingappan K,Coarfa C,Moorthy B
We are looking for graduate students looking to push our research forward while learning vital skill sets for their all-round development as a scientist.
Critical Thinking
Problem Solver
Willing to learn (Growth Mindset)
Self-Motivation
Honesty
Strong work ethic
๐ข Section of Neonatology, Department of Pediatrics
โ๏ธ lingappank AT chop DOT edu