Welcome!

In our lab, we are interested in looking into the mechanisms behind sex-specific differences in lung diseases as it pertains to Neonatology.

Krithika Lingappan portrait

Krithika Lingappan, MD, PhD, MS

Our unique niche is to elucidate the mechanisms sex-specific differences in neonatal hyperoxic lung injury with the goal to develop individualized therapeutic options to decrease morbidity in preterm babies. Sex-specific differences exist in various forms of organ injury in adults and children. Neonatal outcomes for males are worse than females for many diseases, including bronchopulmonary dysplasia (BPD). Being a neonatologist, Dr. Lingappan's interest was in the field of neonatal lung injury and repair.

Meet the rest of the lab ๐Ÿ‘ฉโ€๐Ÿ”ฌ

Latest From the Lab

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Our research

Bronchopulmonary dysplasia (BPD), a debilitating lung disease with long-term consequences, is the most common morbidity in extremely premature neonates. Male babies have a higher incidence of BPD compared to females. We study how lung injury and repair is different between male and female neonates and elucidate the molecular mechanisms modulating these sex-specific differences.

Sprouting Angiogenesis

Sprouting Angiogenesis in male and female human pulmonary microvascular endothelial cells.

Latest Publications

Sex-related external factors influence pulmonary vascular angiogenesis in a sex-dependent manner.

Hayward-Piatkovskyi B,Gonyea CR,Pyle SC,Lingappan K,Gleghorn JP

doi: 10.1152/ajpheart.00552.2022

Published online 2022 Nov 11.

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The Need to Address Sex as a Biological Variable in Neonatal Clinical Studies.

Lingappan K,Alur P,Eichenwald E

doi: 10.1016/j.jpeds.2022.11.021

Published online 2022 Nov 30.

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Lung biopsy in infants with severe bronchopulmonary dysplasia.

Callaway DA,Wang Y,Lingappan K,Pogoriler JE,Laje P,Nilan K,Kirpalani H,Zhang H

doi: 10.1002/ppul.26433

Published online 2023 May 3.

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Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates.

Lingappan K,Neveln N,Arnold JL,Fernandes CJ,Pammi M

doi: 10.1002/14651858.CD009975.pub4

Published online 2023 May 12.

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Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation.

Grimm SL,Stading RE,Robertson MJ,Gandhi T,Fu C,Jiang W,Xia G,Lingappan K,Coarfa C,Moorthy B

doi: 10.1016/j.redox.2023.102790

Published online 2023 Jun 16.

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Open positions

We are looking for graduate students looking to push our research forward while learning vital skill sets for their all-round development as a scientist.

Critical Thinking

Problem Solver

Willing to learn (Growth Mindset)

Self-Motivation

Honesty

Strong work ethic

Sprouting Angiogenesis

Contact Us!

๐Ÿข Section of Neonatology, Department of Pediatrics

โœ‰๏ธ lingappank AT chop DOT edu