Welcome!
In our lab, we are interested in looking into the mechanisms behind sex-specific differences in lung diseases as it pertains to Neonatology.
Krithika Lingappan, MD, PhD, MS
Our unique niche is to elucidate the mechanisms sex-specific differences in neonatal hyperoxic lung injury with the goal to develop individualized therapeutic options to decrease morbidity in preterm babies. Sex-specific differences exist in various forms of organ injury in adults and children. Neonatal outcomes for males are worse than females for many diseases, including bronchopulmonary dysplasia (BPD). Being a neonatologist, Dr. Lingappan's interest was in the field of neonatal lung injury and repair.
Meet the rest of the lab 👩🔬Our research
Bronchopulmonary dysplasia (BPD), a debilitating lung disease with long-term consequences, is the most common morbidity in extremely premature neonates. Male babies have a higher incidence of BPD compared to females. We study how lung injury and repair is different between male and female neonates and elucidate the molecular mechanisms modulating these sex-specific differences.
Sprouting Angiogenesis in male and female human pulmonary microvascular endothelial cells.
Latest Publications
Sex-related external factors influence pulmonary vascular angiogenesis in a sex-dependent manner.
Hayward-Piatkovskyi B,Gonyea CR,Pyle SC,Lingappan K,Gleghorn JP
doi: 10.1152/ajpheart.00552.2022
Published online 2022 Nov 11.
The Need to Address Sex as a Biological Variable in Neonatal Clinical Studies.
Lingappan K,Alur P,Eichenwald E
doi: 10.1016/j.jpeds.2022.11.021
Published online 2022 Nov 30.
Lung biopsy in infants with severe bronchopulmonary dysplasia.
Callaway DA,Wang Y,Lingappan K,Pogoriler JE,Laje P,Nilan K,Kirpalani H,Zhang H
doi: 10.1002/ppul.26433
Published online 2023 May 3.
Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates.
Lingappan K,Neveln N,Arnold JL,Fernandes CJ,Pammi M
doi: 10.1002/14651858.CD009975.pub4
Published online 2023 May 12.
Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation.
Grimm SL,Stading RE,Robertson MJ,Gandhi T,Fu C,Jiang W,Xia G,Lingappan K,Coarfa C,Moorthy B
doi: 10.1016/j.redox.2023.102790
Published online 2023 Jun 16.
Open positions
We are looking for graduate students looking to push our research forward while learning vital skill sets for their all-round development as a scientist.
Critical Thinking
Problem Solver
Willing to learn (Growth Mindset)
Self-Motivation
Honesty
Strong work ethic
Contact Us!
🏢 Section of Neonatology, Department of Pediatrics
✉️ lingappank AT chop DOT edu